Protein ISGylation: a posttranslational modification with implications for malignant neoplasms
Interferon (IFN)-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (UBL) protein family that can modify specific proteins via a catalytic process called ISGylation. This posttranslational modification can modulate the stability of the ISGylated proteins and protein-protein interactions. S...
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| Main Authors: | , |
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| Format: | Book |
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Open Exploration Publishing Inc.,
2023-08-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Interferon (IFN)-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (UBL) protein family that can modify specific proteins via a catalytic process called ISGylation. This posttranslational modification can modulate the stability of the ISGylated proteins and protein-protein interactions. Some proteins modified by ISG15 have been identified in malignant neoplasms, suggesting the functional relevance of ISGylation in cancer. This review discusses the ISGylated proteins reported in malignant neoplasms that suggest the potential of ISG15 as a biomarker and therapeutic target in cancer. |
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| Item Description: | 10.37349/etat.2023.00162 2692-3114 |