Protein ISGylation: a posttranslational modification with implications for malignant neoplasms
Interferon (IFN)-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (UBL) protein family that can modify specific proteins via a catalytic process called ISGylation. This posttranslational modification can modulate the stability of the ISGylated proteins and protein-protein interactions. S...
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Open Exploration Publishing Inc.,
2023-08-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_8474c492f5da4d59a3ab12d6e9a2e505 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Angeles C. Tecalco-Cruz |e author |
| 700 | 1 | 0 | |a Jesús Zepeda-Cervantes |e author |
| 245 | 0 | 0 | |a Protein ISGylation: a posttranslational modification with implications for malignant neoplasms |
| 260 | |b Open Exploration Publishing Inc., |c 2023-08-01T00:00:00Z. | ||
| 500 | |a 10.37349/etat.2023.00162 | ||
| 500 | |a 2692-3114 | ||
| 520 | |a Interferon (IFN)-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (UBL) protein family that can modify specific proteins via a catalytic process called ISGylation. This posttranslational modification can modulate the stability of the ISGylated proteins and protein-protein interactions. Some proteins modified by ISG15 have been identified in malignant neoplasms, suggesting the functional relevance of ISGylation in cancer. This review discusses the ISGylated proteins reported in malignant neoplasms that suggest the potential of ISG15 as a biomarker and therapeutic target in cancer. | ||
| 546 | |a EN | ||
| 690 | |a interferon-stimulated gene 15 | ||
| 690 | |a isgylation | ||
| 690 | |a cancer | ||
| 690 | |a Internal medicine | ||
| 690 | |a RC31-1245 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Exploration of Targeted Anti-tumor Therapy, Vol 4, Iss 4, Pp 699-715 (2023) | |
| 787 | 0 | |n https://www.explorationpub.com/Journals/etat/Article/1002162 | |
| 787 | 0 | |n https://doaj.org/toc/2692-3114 | |
| 856 | 4 | 1 | |u https://doaj.org/article/8474c492f5da4d59a3ab12d6e9a2e505 |z Connect to this object online. |