Cord Blood SARS-CoV-2 IgG Antibodies and Their Association With Maternal Immunity and Neonatal Outcomes

Passive transplacental immunity is crucial for neonatal protection from infections. Data on the correlation between neonatal immunity to SARS-CoV-2 and protection from adverse outcomes is scarce. This work aimed to describe neonatal seropositivity in the context of maternal SARS-CoV-2 infection, ser...

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Main Authors: Addy Cecilia Helguera-Repetto (Author), Isabel Villegas-Mota (Author), Guadalupe Itzel Arredondo-Pulido (Author), Jorge Arturo Cardona-Pérez (Author), Moises León-Juárez (Author), Maria Antonieta Rivera-Rueda (Author), Gabriela Arreola-Ramírez (Author), Paloma Mateu-Rogell (Author), Sandra Acevedo-Gallegos (Author), Gloria Elena López-Navarrete (Author), María Yolotzin Valdespino-Vázquez (Author), Guadalupe Martínez-Salazar (Author), Mario Rodríguez-Bosch (Author), Irma Alejandra Coronado-Zarco (Author), María del Rosario Castillo-Gutiérrez (Author), Carlos Alberto Cuevas-Jiménez (Author), Elsa Romelia Moreno-Verduzco (Author), Salvador Espino- (Author), Manuel Cortés-Bonilla (Author), Claudine Irles (Author)
Format: Book
Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Addy Cecilia Helguera-Repetto  |e author 
700 1 0 |a Isabel Villegas-Mota  |e author 
700 1 0 |a Guadalupe Itzel Arredondo-Pulido  |e author 
700 1 0 |a Jorge Arturo Cardona-Pérez  |e author 
700 1 0 |a Moises León-Juárez  |e author 
700 1 0 |a Maria Antonieta Rivera-Rueda  |e author 
700 1 0 |a Gabriela Arreola-Ramírez  |e author 
700 1 0 |a Paloma Mateu-Rogell  |e author 
700 1 0 |a Sandra Acevedo-Gallegos  |e author 
700 1 0 |a Gloria Elena López-Navarrete  |e author 
700 1 0 |a María Yolotzin Valdespino-Vázquez  |e author 
700 1 0 |a Guadalupe Martínez-Salazar  |e author 
700 1 0 |a Mario Rodríguez-Bosch  |e author 
700 1 0 |a Irma Alejandra Coronado-Zarco  |e author 
700 1 0 |a María del Rosario Castillo-Gutiérrez  |e author 
700 1 0 |a Carlos Alberto Cuevas-Jiménez  |e author 
700 1 0 |a Elsa Romelia Moreno-Verduzco  |e author 
700 1 0 |a Salvador Espino-  |e author 
700 1 0 |a Manuel Cortés-Bonilla  |e author 
700 1 0 |a Claudine Irles  |e author 
245 0 0 |a Cord Blood SARS-CoV-2 IgG Antibodies and Their Association With Maternal Immunity and Neonatal Outcomes 
260 |b Frontiers Media S.A.,   |c 2022-06-01T00:00:00Z. 
500 |a 2296-2360 
500 |a 10.3389/fped.2022.883185 
520 |a Passive transplacental immunity is crucial for neonatal protection from infections. Data on the correlation between neonatal immunity to SARS-CoV-2 and protection from adverse outcomes is scarce. This work aimed to describe neonatal seropositivity in the context of maternal SARS-CoV-2 infection, seropositivity, and neonatal outcomes. This retrospective nested case-control study enrolled high-risk pregnant women with a SARS-CoV-2 RT-PCR positive test who gave birth at the Instituto Nacional de Perinatología in Mexico City and their term neonates. Anti-SARS-CoV-2 IgG antibodies in maternal and cord blood samples were detected using a chemiluminescent assay. In total, 63 mother-neonate dyads (mean gestational age 38.4 weeks) were included. Transplacental transfer of SARS-CoV-2 IgG occurred in 76% of neonates from seropositive mothers. A positive association between maternal IgG levels and Cycle threshold (Ct) values of RT-qPCR test for SARS-CoV-2 with neonatal IgG levels was observed. Regarding neonatal outcomes, most seropositive neonates did not require any mechanical ventilation, and none developed any respiratory morbidity (either in the COVID-19 positive or negative groups) compared to 7 seronegative neonates. Furthermore, the odds of neonatal respiratory morbidity exhibited a tendency to decrease when neonatal IgG levels increase. These results add further evidence suggesting passive IgG transfer importance. 
546 |a EN 
690 |a pregnancy 
690 |a COVID-19 
690 |a newborn 
690 |a seropositivity 
690 |a SARS-CoV-2 antibodies 
690 |a Pediatrics 
690 |a RJ1-570 
655 7 |a article  |2 local 
786 0 |n Frontiers in Pediatrics, Vol 10 (2022) 
787 0 |n https://www.frontiersin.org/articles/10.3389/fped.2022.883185/full 
787 0 |n https://doaj.org/toc/2296-2360 
856 4 1 |u https://doaj.org/article/84769f6d1b7f4d349891f57f00c98e08  |z Connect to this object online.