Cord Blood SARS-CoV-2 IgG Antibodies and Their Association With Maternal Immunity and Neonatal Outcomes
Passive transplacental immunity is crucial for neonatal protection from infections. Data on the correlation between neonatal immunity to SARS-CoV-2 and protection from adverse outcomes is scarce. This work aimed to describe neonatal seropositivity in the context of maternal SARS-CoV-2 infection, ser...
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Frontiers Media S.A.,
2022-06-01T00:00:00Z.
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001 | doaj_84769f6d1b7f4d349891f57f00c98e08 | ||
042 | |a dc | ||
100 | 1 | 0 | |a Addy Cecilia Helguera-Repetto |e author |
700 | 1 | 0 | |a Isabel Villegas-Mota |e author |
700 | 1 | 0 | |a Guadalupe Itzel Arredondo-Pulido |e author |
700 | 1 | 0 | |a Jorge Arturo Cardona-Pérez |e author |
700 | 1 | 0 | |a Moises León-Juárez |e author |
700 | 1 | 0 | |a Maria Antonieta Rivera-Rueda |e author |
700 | 1 | 0 | |a Gabriela Arreola-Ramírez |e author |
700 | 1 | 0 | |a Paloma Mateu-Rogell |e author |
700 | 1 | 0 | |a Sandra Acevedo-Gallegos |e author |
700 | 1 | 0 | |a Gloria Elena López-Navarrete |e author |
700 | 1 | 0 | |a María Yolotzin Valdespino-Vázquez |e author |
700 | 1 | 0 | |a Guadalupe Martínez-Salazar |e author |
700 | 1 | 0 | |a Mario Rodríguez-Bosch |e author |
700 | 1 | 0 | |a Irma Alejandra Coronado-Zarco |e author |
700 | 1 | 0 | |a María del Rosario Castillo-Gutiérrez |e author |
700 | 1 | 0 | |a Carlos Alberto Cuevas-Jiménez |e author |
700 | 1 | 0 | |a Elsa Romelia Moreno-Verduzco |e author |
700 | 1 | 0 | |a Salvador Espino- |e author |
700 | 1 | 0 | |a Manuel Cortés-Bonilla |e author |
700 | 1 | 0 | |a Claudine Irles |e author |
245 | 0 | 0 | |a Cord Blood SARS-CoV-2 IgG Antibodies and Their Association With Maternal Immunity and Neonatal Outcomes |
260 | |b Frontiers Media S.A., |c 2022-06-01T00:00:00Z. | ||
500 | |a 2296-2360 | ||
500 | |a 10.3389/fped.2022.883185 | ||
520 | |a Passive transplacental immunity is crucial for neonatal protection from infections. Data on the correlation between neonatal immunity to SARS-CoV-2 and protection from adverse outcomes is scarce. This work aimed to describe neonatal seropositivity in the context of maternal SARS-CoV-2 infection, seropositivity, and neonatal outcomes. This retrospective nested case-control study enrolled high-risk pregnant women with a SARS-CoV-2 RT-PCR positive test who gave birth at the Instituto Nacional de Perinatología in Mexico City and their term neonates. Anti-SARS-CoV-2 IgG antibodies in maternal and cord blood samples were detected using a chemiluminescent assay. In total, 63 mother-neonate dyads (mean gestational age 38.4 weeks) were included. Transplacental transfer of SARS-CoV-2 IgG occurred in 76% of neonates from seropositive mothers. A positive association between maternal IgG levels and Cycle threshold (Ct) values of RT-qPCR test for SARS-CoV-2 with neonatal IgG levels was observed. Regarding neonatal outcomes, most seropositive neonates did not require any mechanical ventilation, and none developed any respiratory morbidity (either in the COVID-19 positive or negative groups) compared to 7 seronegative neonates. Furthermore, the odds of neonatal respiratory morbidity exhibited a tendency to decrease when neonatal IgG levels increase. These results add further evidence suggesting passive IgG transfer importance. | ||
546 | |a EN | ||
690 | |a pregnancy | ||
690 | |a COVID-19 | ||
690 | |a newborn | ||
690 | |a seropositivity | ||
690 | |a SARS-CoV-2 antibodies | ||
690 | |a Pediatrics | ||
690 | |a RJ1-570 | ||
655 | 7 | |a article |2 local | |
786 | 0 | |n Frontiers in Pediatrics, Vol 10 (2022) | |
787 | 0 | |n https://www.frontiersin.org/articles/10.3389/fped.2022.883185/full | |
787 | 0 | |n https://doaj.org/toc/2296-2360 | |
856 | 4 | 1 | |u https://doaj.org/article/84769f6d1b7f4d349891f57f00c98e08 |z Connect to this object online. |