POM analyses, immunomodulatory, cytotoxic activities and polyphenolic constituents of Callistemon viridiflorus fruits
Phytochemical study on 80% ethanolic extract of Callistemon viridiflorus Sims fruits (CVF) resulted in isolation of five phenolic compounds 1; Gallic acid, 2; Ellagic acid, 3; Reynoutrin, 4; Methoxy ellagic acid, 5; Quercetin. Petra/Osiris/Molinspiration (POM) analyses predicted that Reynoutrin and...
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Faculty of Pharmacy, Cairo University,
2018-12-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_847928d7becf4a3d95a8e35e8bed0219 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Mohamed I.S. Abdelhady |e author |
| 700 | 1 | 0 | |a Amel M. Kamal |e author |
| 700 | 1 | 0 | |a Mohamed F. Barghash |e author |
| 245 | 0 | 0 | |a POM analyses, immunomodulatory, cytotoxic activities and polyphenolic constituents of Callistemon viridiflorus fruits |
| 260 | |b Faculty of Pharmacy, Cairo University, |c 2018-12-01T00:00:00Z. | ||
| 500 | |a 1110-0931 | ||
| 500 | |a 10.1016/j.bfopcu.2018.06.001 | ||
| 520 | |a Phytochemical study on 80% ethanolic extract of Callistemon viridiflorus Sims fruits (CVF) resulted in isolation of five phenolic compounds 1; Gallic acid, 2; Ellagic acid, 3; Reynoutrin, 4; Methoxy ellagic acid, 5; Quercetin. Petra/Osiris/Molinspiration (POM) analyses predicted that Reynoutrin and Quercetin have interesting potential activities, also Reynoutrin is found to be safer in relation to Quercetin. 80% ethanolic extract of CVF, Reynoutrin and Quercetin displayed remarkable immunomodulatory activity, as increased proliferation of RAW 264.7 macrophage cells by 1.48, 1.51 and 1.46 fold respectively. 80% ethanolic extract of the C. viridiflorus fruits showed significant cytotoxic activity against P388 leukemia cells (IC50 = 15.11 µg/ml), followed by Quercetin (IC50 = 21.5 µg/ml) then Reynoutrin (IC50 = 33.32 µg/ml). Keywords: POM analyses, Callistemon viridiflorus, Polyphenols, Immunomodulatory, Cytotoxic | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 690 | |a Pharmaceutical industry | ||
| 690 | |a HD9665-9675 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Bulletin of Faculty of Pharmacy Cairo University, Vol 56, Iss 2, Pp 175-178 (2018) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1110093118300255 | |
| 787 | 0 | |n https://doaj.org/toc/1110-0931 | |
| 856 | 4 | 1 | |u https://doaj.org/article/847928d7becf4a3d95a8e35e8bed0219 |z Connect to this object online. |