Pleomorphic Onychomatricoma: A Mimicker of Malignancy

Pleomorphic onychomatricoma is a rare condition mimicking malignant neoplasms. Given its rarity, the diagnostic and prognostic criteria of this condition are not well established. The aim of this study was to characterize a series of 6 cases of pleomorphic onychomatricoma. In 3 cases the submitting...

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Main Authors: Christophe Perrin (Author), Damien Ambrosetti (Author)
Format: Book
Published: Medical Journals Sweden, 2022-01-01T00:00:00Z.
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100 1 0 |a Christophe Perrin  |e author 
700 1 0 |a Damien Ambrosetti  |e author 
245 0 0 |a Pleomorphic Onychomatricoma: A Mimicker of Malignancy 
260 |b Medical Journals Sweden,   |c 2022-01-01T00:00:00Z. 
500 |a 10.2340/actadv.v101.546 
500 |a 0001-5555 
500 |a 1651-2057 
520 |a Pleomorphic onychomatricoma is a rare condition mimicking malignant neoplasms. Given its rarity, the diagnostic and prognostic criteria of this condition are not well established. The aim of this study was to characterize a series of 6 cases of pleomorphic onychomatricoma. In 3 cases the submitting clinical diagnosis was subungual squamous cell carcinoma. For all 6 cases, nail clipping showed typical features of onychomatricoma as a free-edge thickening and pitting of the nail plate with an additional feature of projecting line pattern. Pleomorphic onychomatricoma was diagnosed based on moderate-severe cytological atypia, yet degenerative-appearing with multinucleation or smudged chromatin, no mitotic activity or necrosis, and a Ki67 proliferative index inferior to 5% overall. Other finding s included epithelioid multinucleated cells with deeply eosinophilic cytoplasm mimicking epithelioid malignant cells, overexpression of Ki67 and p53 on atypical cells and diffuse expression of p16. This study describes additional criteria in pleomorphic onychomatricoma, permitting a wider recognition in order to avoid inappropriate treatment. 
546 |a EN 
690 |a onychomatricoma 
690 |a pleomorphic onychomatricoma 
690 |a superficial CD34-positive fibroblastic tumour 
690 |a superficial acral fibromyxoma 
690 |a nail tumour 
690 |a subungual squamous cell carcinoma 
690 |a Dermatology 
690 |a RL1-803 
655 7 |a article  |2 local 
786 0 |n Acta Dermato-Venereologica, Vol 102 (2022) 
787 0 |n https://medicaljournalssweden.se/actadv/article/view/546 
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787 0 |n https://doaj.org/toc/1651-2057 
856 4 1 |u https://doaj.org/article/848413f5b4c543fabc74ec4816a5a4b1  |z Connect to this object online.