Gender-specific association between night-work exposure and type-2 diabetes: results from longitudinal study of adult health, ELSA-Brasil

• Huvudupphovsmän: Aline Silva-Costa (Författare, medförfattare), Lúcia Rotenberg (Författare, medförfattare), Aline Araújo Nobre (Författare, medförfattare), Maria Inês Schmidt (Författare, medförfattare), Dóra Chor (Författare, medförfattare), Rosane Härter Griep (Författare, medförfattare)
• Materialtyp: Bok
• Publicerad: Nordic Association of Occupational Safety and Health (NOROSH), 2015-11-01T00:00:00Z.
• Ämnen: article
• Länkar: Connect to this object online.
• Notes: 0355-3140; 1795-990X; 10.5271/sjweh.3520
• Keywords: elsa-brasil; longitudinal study; sex difference; health; gender; night work; work schedule; diabetes; night shift; brazil; impaired glucose tolerance; gender-specific association; type-2 diabetes; Public aspects of medicine; RA1-1270
• Source: Scandinavian Journal of Work, Environment & Health, Vol 41, Iss 6, Pp 569-578 (2015)

OBJECTIVES: Diabetes is a multifactorial disease of increasing prevalence. The literature suggests an impact of night work on metabolic components, though the relationship with diabetes is unclear. Our aim was to investigate gender-specific associations between night work and type-2 diabetes (DM2) or impaired glucose tolerance (IGT) using baseline data of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). METHODS: The cohort comprised 15 105 civil servants, aged 35-74 years. Baseline assessments (2008-2010) included clinical and laboratory measurements and interviews on sociodemographic, occupational, and health characteristics. RESULTS: In the baseline sample (N=14 427), 19.6% were classified as having DM2 and 20.5% as having IGT. Mean age was 52.1 (SD 9.1) years. A total of 2041 participants worked at night for 1-20 years and 687 for >20 years. Among women exposed to night work for >20 years compared with no night work after adjustments for potential confounders, including obesity, the odds ratios (OR) derived from multinomial logistic regression for DM2 and IGT were 1.42 [95% confidence interval (95% CI) 1.39-1.45] and 0.96 (95% CI 0.94-0.99), respectively. Among men exposed to night work for >20 years compared with no night work, the OR for DM2 and IGT were 1.06 (95% CI 1.04-1.08) and 0.99 (95% CI 0.98-1.01), respectively. CONCLUSIONS: The association between years of night work and diabetes is stronger among women than men. Longitudinal studies from ELSA-Brasil will be able to corroborate or refute these findings.