Antibiotic Resistance of <i>Streptococcus pneumoniae</i> in the Nasopharynx of Healthy Children Less than Five Years Old after the Generalization of Pneumococcal Vaccination in Marrakesh, Morocco
<i>Streptococcus pneumoniae</i> (<i>S. pneumoniae</i>) remains one of the most important pathogens causing childhood infections. The spread of antibiotic-resistant bacteria is a leading cause of treatment failure in children. The purpose of this investigation is to report the...
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| Main Authors: | , , , , , , , , |
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| Format: | Book |
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MDPI AG,
2023-02-01T00:00:00Z.
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| Summary: | <i>Streptococcus pneumoniae</i> (<i>S. pneumoniae</i>) remains one of the most important pathogens causing childhood infections. The spread of antibiotic-resistant bacteria is a leading cause of treatment failure in children. The purpose of this investigation is to report the antibiotic and multidrug resistance (MDR) of <i>S. pneumoniae</i> strains isolated from healthy children throughout the years 2020-2022. Antimicrobial susceptibility testing of <i>S. pneumoniae</i> strains in selected antimicrobials was performed using disk diffusion and E-test methods on bloodMueller-Hinton agar. The antimicrobials tested included oxacillin, amoxicillin, ceftriaxone, norfloxacin, gentamicin, vancomycin, erythromycin, clindamycin, pristinamycin, tetracycline, chloramphenicol, and trimethoprim-sulfamethoxazole. A total of 201 <i>S. pneumoniae</i> strains were isolated from the nasopharynx of healthy children in Marrakesh, Morocco. The highest rate of resistance of <i>S. pneumoniae</i> was found in penicillin (57.2%), followed by tetracycline (20.9%), and erythromycin (17.9%). The rates of resistance to clindamycin, trimethoprim-sulfamethoxazole, and chloramphenicol were 14.9%, 4%, and 1.5%, respectively. All isolates were susceptible to norfloxacin, gentamicin, vancomycin, and pristinamycin. Approximately 17% of all <i>S. pneumoniae</i> strains were resistant to at least three different antibiotic families. This study showed a low rate of antibiotics resistance among nasopharyngeal <i>S. pneumoniae</i> strains, and it is thus essential to monitor <i>S. pneumoniae</i> susceptibility in healthy children. |
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| Item Description: | 10.3390/antibiotics12030442 2079-6382 |