Indirect SPECT Imaging Evaluation for Possible Nose-to-Brain Drug Delivery Using a Compound with Poor Blood-Brain Barrier Permeability in Mice

• Main Authors: Asuka Mizutani (Author), Masato Kobayashi (Author), Makoto Ohuchi (Author), Keita Sasaki (Author), Yuka Muranaka (Author), Yusuke Torikai (Author), Shota Fukakusa (Author), Chie Suzuki (Author), Ryuichi Nishii (Author), Shunji Haruta (Author), Yasuhiro Magata (Author), Keiichi Kawai (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Single-photon emission computed tomography (SPECT) imaging using intravenous radioactive ligand administration to indirectly evaluate the time-dependent effect of intranasal drugs with poor blood-brain barrier permeability on brain drug distributions in mice was evaluated. The biodistribution was ex...