Study of the mass balance, biotransformation and safety of [14C]SHR8554, a novel μ-opioid receptor injection, in healthy Chinese subjects

• Ngā kaituhi matua: Rupeng Shi (Author), Yi Chai (Author), Hao Feng (Author), Lijun Xie (Author), Lulu Zhang (Author), Tianqi Zhong (Author), Juan Chen (Author), Peng Yan (Author), Bei Zhu (Author), Jun Zhao (Author), Chen Zhou (Author)
• Hōputu: Pukapuka
• I whakaputaina: Frontiers Media S.A., 2023-09-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Background: SHR8554 is a novel μ-opioid receptor-biased agonist. It has analgesic effects by selectively activating the G protein-coupled pathway. Additionally, it can weakly activate the ß-arrestin-2 pathway, resulting in a limited number of side effects, such as gastrointestinal inhibition. Previo...