Study of the mass balance, biotransformation and safety of [14C]SHR8554, a novel μ-opioid receptor injection, in healthy Chinese subjects

• Main Authors: Rupeng Shi (Author), Yi Chai (Author), Hao Feng (Author), Lijun Xie (Author), Lulu Zhang (Author), Tianqi Zhong (Author), Juan Chen (Author), Peng Yan (Author), Bei Zhu (Author), Jun Zhao (Author), Chen Zhou (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: SHR8554 is a novel μ-opioid receptor-biased agonist. It has analgesic effects by selectively activating the G protein-coupled pathway. Additionally, it can weakly activate the ß-arrestin-2 pathway, resulting in a limited number of side effects, such as gastrointestinal inhibition. Previo...