Sarcomatoid carcinoma of the upper aerodigestive tract: An immunohistochemical analysis demonstrating latent <i>Epstein-Barr</i> virus in a subset of eight cases
<b>Background:</b> Sarcomatoid or spindle cell carcinomas are rare malignancies which are considered as a poorly differentiated variant of squamous cell carcinoma. <i>Epstein-Barr</i> virus (EBV) is associated with a wide variety of malignancies. <b>Materials and Method...
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| Main Authors: | , , , , |
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| Format: | Book |
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Wolters Kluwer Medknow Publications,
2010-10-01T00:00:00Z.
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| Summary: | <b>Background:</b> Sarcomatoid or spindle cell carcinomas are rare malignancies which are considered as a poorly differentiated variant of squamous cell carcinoma. <i>Epstein-Barr</i> virus (EBV) is associated with a wide variety of malignancies. <b>Materials and Methods:</b> We examined the expression of EBV latent membrane protein-1 (LMP-1) and EBV EBNA-2 as well as the immunohistochemical profile of AE-1/AE-3, vimentin, desmin, CK 5-6, smooth muscle actin (SMA), p63, S-100, p53 and CD-117 with the clinicopathological correlation of eight patients of sarcomatoid carcinoma (SC) in the upper aerodigestive tract. <b>Results:</b> Four cases showed EBV LMP-1 positivity (50%) and there was no EBV EBNA-2 positivity. However, the EBV LMP-1 results of our series could be considered only as a coincidental finding in the SCs of the upper aerodigestive tract. <b>Conclusions:</b> This finding supports the idea that further studies based on larger series might be helpful enlighting the role played by EBV in carcinogenesis of SC. |
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| Item Description: | 0377-4929 0974-5130 |