Hot Melt Extrusion-Triggered Amorphization as a Continuous Process for Inducing Extended Supersaturable Drug Immediate-Release from saSMSDs Systems

• Main Authors: Huan Yu (Author), Yanfei Zhang (Author), Yinghui Ma (Author), Huifeng Zhang (Author), Chengyi Hao (Author), Yong Zhang (Author), Zhengqiang Li (Author), Xianrong Qi (Author), Nianqiu Shi (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hot melt extrusion (HME), a continuous manufacturing process for generating supersaturating amorphous self-micellizing solid dispersion systems (saSMSDs), holds promise for achieving amorphization of many pharmaceutical formulations. For saSMSDs generation, HME-triggered continuous processes offer a...