Complete Hydatidiform Mole with a Coexisting Viable Male Fetus Detected by Cell-Free DNA
Complete hydatidiform mole with coexisting fetus (CHMCF) is rare, and diagnosis is challenging due to limited data. Here, we present the case of a patient with noninvasive prenatal test (NIPT) resulting in "likely molar pregnancy" in the second trimester. Subsequent ultrasound confirmed a...
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| Main Authors: | , , , , , , , , |
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| Format: | Book |
| Published: |
Thieme Medical Publishers, Inc.,
2023-07-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Complete hydatidiform mole with coexisting fetus (CHMCF) is rare, and diagnosis is challenging due to limited data. Here, we present the case of a patient with noninvasive prenatal test (NIPT) resulting in "likely molar pregnancy" in the second trimester. Subsequent ultrasound confirmed a cystic appearing portion of the placenta. At 22 weeks, the patient delivered a demised fetus and two placentas. Pathology was consistent with CHMCF. This case is the first to show primary detection of a CHMCF with single-nucleotide polymorphism (SNP)-based NIPT prior to ultrasound identification. Our case suggests the use of SNP-based NIPT as an alternative noninvasive method to guide shared decision-making and clinical management for patients with this diagnosis. |
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| Item Description: | 2157-6998 2157-7005 10.1055/s-0043-1774727 |