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The Structure and Activity of Double-Nitroimidazoles. A Mini-Review

Many interesting applications have been found for nitroimidazoles as therapeutic agents. Among others, some of these compounds can radiosensitize hypoxic tumor cells. The introduction of a second nitroimidazole ring to the molecule can improve the level of its pharmacological effect. The aim of this...

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Bibliographic Details
Main Authors: Justyna Żwawiak (Author), Lucjusz Zaprutko (Author)
Format: Book
Published: MDPI AG, 2018-07-01T00:00:00Z.
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100 1 0 |a Justyna Żwawiak  |e author 
700 1 0 |a Lucjusz Zaprutko  |e author 
245 0 0 |a The Structure and Activity of Double-Nitroimidazoles. A Mini-Review 
260 |b MDPI AG,   |c 2018-07-01T00:00:00Z. 
500 |a 2218-0532 
500 |a 10.3390/scipharm86030030 
520 |a Many interesting applications have been found for nitroimidazoles as therapeutic agents. Among others, some of these compounds can radiosensitize hypoxic tumor cells. The introduction of a second nitroimidazole ring to the molecule can improve the level of its pharmacological effect. The aim of this article is to overview the literature concerning active compounds that contain two nitroimidazole moieties in their structures. 
546 |a EN 
690 |a nitroimidazoles 
690 |a double-nitroimidazoles 
690 |a bis-nitroimidazoles 
690 |a tumor hypoxia 
690 |a radiosensitizers 
690 |a Pharmacy and materia medica 
690 |a RS1-441 
655 7 |a article  |2 local 
786 0 |n Scientia Pharmaceutica, Vol 86, Iss 3, p 30 (2018) 
787 0 |n http://www.mdpi.com/2218-0532/86/3/30 
787 0 |n https://doaj.org/toc/2218-0532 
856 4 1 |u https://doaj.org/article/857b64e8d8b4447ca37c8d3385a9a59c  |z Connect to this object online. 

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