Prevention of preeclampsia in pregnant women with obesity

<p>Reducing the occurrence of preeclampsia is one of the key tasks in modern obstetrics, especially in pregnant women with concomitant obesity, who are at high risk for preeclampsia, the leading pathogenetic segment of which is endothelial dysfunction. The purpose of this work is to evaluate t...

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Main Authors: Marta Zelinka-Khobzey (Author), Kostiantyn Tarasenko (Author), Tatyana Mamontova (Author), Oksana Shlykova (Author)
Format: Book
Published: Kazimierz Wielki University, 2021-03-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Marta Zelinka-Khobzey  |e author 
700 1 0 |a Kostiantyn Tarasenko  |e author 
700 1 0 |a Tatyana Mamontova  |e author 
700 1 0 |a Oksana Shlykova  |e author 
245 0 0 |a Prevention of preeclampsia in pregnant women with obesity 
260 |b Kazimierz Wielki University,   |c 2021-03-01T00:00:00Z. 
500 |a 2391-8306 
500 |a 10.12775/JEHS.2021.11.03.018 
520 |a <p>Reducing the occurrence of preeclampsia is one of the key tasks in modern obstetrics, especially in pregnant women with concomitant obesity, who are at high risk for preeclampsia, the leading pathogenetic segment of which is endothelial dysfunction. The purpose of this work is to evaluate the effectiveness of the integrated therapeutic and preventive complex (TPC) in order to prevent preeclampsia in pregnant women. These parameters were evaluated using such markers as the concentration of vascular endothelial growth factor (VEGF) in blood serum and the content of circulating endothelial microparticles (CEM) CD32<sup>+</sup>CD40<sup>+</sup> in peripheral blood in pregnant women with obesity of varying severity over the course of treatment we proposed. 110 pregnant women were included in the study: women with physiological body weight (n=26); women with class I obesity (n=42), and women with class II-III obesity. The groups of pregnant women with concomitant obesity were divided into two equal subgroups; one of the subgroups received the TPC (acetylsalicylic acid, calcium supplements, L-arginine, diosmin). The findings obtained demonstrate a significant improvement of endothelial status over the course of the therapy that is manifested with an increase in the serum VEGF concentration and a decrease in the content of CD32<sup>+</sup>CD40<sup>+</sup> CEM in the peripheral blood. Our clinical assessment of pregnancy course, childbirth and the postpartum period in women with obesity and physiological body weight has shown a decrease in the occurrence of complications due to taking the integrated TPC. We have registered a decrease in the incidence of preeclampsia, placental dysfunction, occurrence of miscarriage, operative delivery and postpartum complications.</p> 
546 |a EN 
546 |a ES 
546 |a PL 
546 |a RU 
546 |a UK 
690 |a vascular endothelial growth factor 
690 |a circulating endothelial microparticles cd32+cd40+ 
690 |a endothelial dysfunction 
690 |a preeclampsia 
690 |a pregnancy 
690 |a obesity 
690 |a Education 
690 |a L 
690 |a Sports 
690 |a GV557-1198.995 
690 |a Medicine 
690 |a R 
655 7 |a article  |2 local 
786 0 |n Journal of Education, Health and Sport, Vol 11, Iss 3, Pp 175-188 (2021) 
787 0 |n https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/33825 
787 0 |n https://doaj.org/toc/2391-8306 
856 4 1 |u https://doaj.org/article/857dba47f6cf4f4daad690f8149ebd3d  |z Connect to this object online.