A Sox17 downstream gene Rasip1 is involved in the hematopoietic activity of intra-aortic hematopoietic clusters in the midgestation mouse embryo

• Main Authors: Gerel Melig (Author), Ikuo Nobuhisa (Author), Kiyoka Saito (Author), Ryota Tsukahara (Author), Ayumi Itabashi (Author), Yoshiakira Kanai (Author), Masami Kanai-Azuma (Author), Mitsujiro Osawa (Author), Motohiko Oshima (Author), Atsushi Iwama (Author), Tetsuya Taga (Author)
• Format: Book
• Published: BMC, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background During mouse embryonic development, definitive hematopoiesis is first detected around embryonic day (E) 10.5 in the aorta-gonad-mesonephros (AGM) region. Hematopoietic stem cells (HSCs) arise in the dorsal aorta's intra-aortic hematopoietic cell clusters (IAHCs). We have pre...