Synthesis of Some Substituted Benzoxazole [3,4-b] imidazoles
ABSTRACT<br /> In this paper the synthesis of 4-substituted benzoxazole [3,4-b] imidazole (9,10) and 4-aryl hexahydrobenzoxazole [3,4-b] imidazole (13,14) is reported. Glycine was treated with benzoyl chloride or p-nitrobenzoyl chloride to give N-aroyl glycine (1,2), the reaction of N-aroyl gl...
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College of Education for Pure Sciences,
2008-09-01T00:00:00Z.
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| Summary: | ABSTRACT<br /> In this paper the synthesis of 4-substituted benzoxazole [3,4-b] imidazole (9,10) and 4-aryl hexahydrobenzoxazole [3,4-b] imidazole (13,14) is reported. Glycine was treated with benzoyl chloride or p-nitrobenzoyl chloride to give N-aroyl glycine (1,2), the reaction of N-aroyl glycine with thionyl chloride followed by treatment the product (3,4) with ammonium hydroxide to give N-aroyl glycine amide (5,6). Treatment of the amide with 1-bromocyclohexanone gave N-methylene-2-hexahydrobenzoxazole) aryl amide (7,8), cyclization of this gave product (9,10), whereas the compounds (13,14) was synthesized from o-aminophenol and the acid chlorides to give N-methylene (2-benzoxazole) aryl amide (11,12) which cyclized with phosphorous oxychloride to give the products (13,14).<br /> The structure of all synthesized compounds were confirmed by physical and spectral data. |
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| Item Description: | 1812-125X 2664-2530 10.33899/edusj.2008.56050 |