Head-to-Head Comparison between [⁶⁸Ga]Ga-DOTA.SA.FAPi and [¹⁸F]F-FDG PET/CT Imaging in Patients with Breast Cancer

• Main Authors: Sanjana Ballal (Author), Madhav P. Yadav (Author), Frank Roesch (Author), Nicky Wakade (Author), Shobhana Raju (Author), Parvind Sheokand (Author), Prashant Mishra (Author), Euy Sung Moon (Author), Madhavi Tripathi (Author), Marcel Martin (Author), Chandrasekhar Bal (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

This study aimed to compare the diagnostic performance of [⁶⁸Ga]Ga-DOTA.SA.FAPi with that of [¹⁸F]F-FDG PET/CT in detecting primary and metastatic lesions of breast cancer. [¹⁸F]F-FDG and [⁶⁸Ga]Ga-DOTA.SA.FAPi PET/CT scans of histologically proven breast cancer patients were compared according to patient-based and lesion-based analysis. Forty-seven patients with a mean age of 44.8 ± 9.9 years (range: 31-66 years) were evaluated. A total of 85% of patients had invasive ductal carcinoma, and 15% had invasive lobular carcinoma. The tracer uptake [SULpeak, SULavg, and the median tumor-to-background ratio (TBR)] was significantly higher in [⁶⁸Ga]Ga-DOTA.SA.FAPi than with [¹⁸F]F-FDG PET/CT for lymph nodes, pleural metastases, and liver lesions (<i>p</i> < 0.05). However, for brain metastasis, only the median TBR was significantly higher (<i>p</i> < 0.05) compared to [¹⁸F]F-FDG. In patient-based analysis the sensitivity of [⁶⁸Ga]Ga-DOTA.SA.FAPi PET/CT was higher, but not significant than that of [¹⁸F]F-FDG PET/CT in the detection of both primary tumors and metastatic lesions. According to lesion-based analysis, on diagnostic CT, 47 patients had 44 primary tumors, 248 lymph nodes, 15 pleural, 88 liver, and 42 brain metastases. [⁶⁸Ga]Ga-DOTA.SA.FAPi scan identified more abnormal lesions than [¹⁸F]F-FDG in all the primary and metastatic sites with a maximum marked difference in the primary site [88.6% vs. 81.8%; <i>p</i>-0.001], lymph nodes [89.1% vs. 83.8%; <i>p</i>-0.0001], pleural metastases [93.3% vs. 73%; <i>p</i>-0.096] and brain metastasis [100% vs. 59.5%; <i>p</i>-0.0001]. [⁶⁸Ga]Ga-DOTA.SA.FAPi PET/CT was superior to [¹⁸F]F-FDG PET/CT in the imaging of breast cancers.

Item Description

10.3390/ph16040521
1424-8247