The Effects of Selective Serotonin-Reuptake Inhibitor on Visual Evoked Potential in Rats
The present study was undertaken to clarify the effects of selective serotonin-reuptake inhibitors (SSRIs) on visual evoked potential (VEP) in rats. To elucidate the mechanism of action of SSRIs, some serotonin (5-HT) agonists were used. SSRIs, fluvoxamine and paroxetine, caused a reduction in the a...
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| Main Authors: | , , |
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| Format: | Book |
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Elsevier,
2004-01-01T00:00:00Z.
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| Summary: | The present study was undertaken to clarify the effects of selective serotonin-reuptake inhibitors (SSRIs) on visual evoked potential (VEP) in rats. To elucidate the mechanism of action of SSRIs, some serotonin (5-HT) agonists were used. SSRIs, fluvoxamine and paroxetine, caused a reduction in the amplitudes of P1-N1, P3-N3, and N3-P4 components of VEP. The amplitude of the P1-N1 component was also reduced by the 5-HT1A agonist 8-OH-DPAT and 5-HT1B agonist anpirtoline. On the other hand, amplitudes of P3-N3 and N3-P4 components were reduced by anpirtoline and the 5-HT2 agonist DOI. These results indicate that the reduction in the amplitude of the P1-N1 component of VEP induced by SSRIs may participate in 5-HT1A and 5-HT1B receptors, and those of P3-N3 and N3-P4 components induced by SSRIs may be closely related with 5-HT1B and 5-HT2 receptors. Keywords:: serotonin, fluvoxamine, paroxetine, visual evoked potential |
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| Item Description: | 1347-8613 10.1254/jphs.94.271 |