Cover Image

The design and synthesis of dextran-doxorubicin prodrug-based pH-sensitive drug delivery system for improving chemotherapy efficacy

Tumor cells show acidic conditions compared with normal cells, which further inspires scientist to build nanocarrier responsive to tumor microenvironment (TME) for enhancing tumor therapeutic efficacy. Here, we report a pH-sensitive and biocompatible polyprodrug based on dextran-doxorubicin (DOX) pr...

Full description

Saved in:

Bibliographic Details
Main Authors:	Xiaoli Zhang (Author), Tian Zhang (Author), Xianbin Ma (Author), Yajun Wang (Author), Yi Lu (Author), Die Jia (Author), Xiaohua Huang (Author), Jiucun Chen (Author), Zhigang Xu (Author), Feiqiu Wen (Author)
Format:	Book
Published:	Elsevier, 2020-09-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Synergistic Combination Chemotherapy of Lung Cancer: Cisplatin and Doxorubicin Conjugated Prodrug Loaded, Glutathione and pH Sensitive Nanocarriers
by: Jin Y, et al.
Published: (2020)

ROS-Responsive and pH-Sensitive Aminothiols Dual-Prodrug for Radiation Enteritis
by: Yuanfang Chen, et al.
Published: (2022)

Synthesis and evaluation of hydrogen peroxide sensitive tofacitinib prodrugs
by: Viola Previtali, et al.
Published: (2022)

Engineered bovine serum albumin-based nanoparticles with pH-sensitivity for doxorubicin delivery and controlled release
by: Zhihang Yang, et al.
Published: (2020)

pH-triggered dynamic erosive small molecule chlorambucil nano-prodrugs mediate robust oral chemotherapy
by: Xin Liu, et al.
Published: (2023)

Sustained and Targeted Delivery of Self-Assembled Doxorubicin Nonapeptides Using pH-Responsive Hydrogels for Osteosarcoma Chemotherapy
by: Jie Zhu, et al.
Published: (2023)

A Theranostic Nanocomplex Combining with Magnetic Hyperthermia for Enhanced Accumulation and Efficacy of pH-Triggering Polymeric Cisplatin(IV) Prodrugs
by: Yang Qu, et al.
Published: (2022)

Bicomponent polymeric micelles for pH-controlled delivery of doxorubicin
by: Chunyun Wang, et al.
Published: (2020)

pH-Sensitive Targeting of Tumors with Chemotherapy-Laden Nanoparticles: Progress and Challenges
by: Zuha Imtiyaz, et al.
Published: (2022)

Endosomal pH, Redox Dual-Sensitive Prodrug Micelles Based on Hyaluronic Acid for Intracellular Camptothecin Delivery and Active Tumor Targeting in Cancer Therapy
by: Huiping Zhang, et al.
Published: (2024)

Surface modification of doxorubicin-loaded nanoparticles based on polydopamine with pH-sensitive property for tumor targeting therapy
by: Dongdong Bi, et al.
Published: (2018)

An On-Demand pH-Sensitive Nanocluster for Cancer Treatment by Combining Photothermal Therapy and Chemotherapy
by: Taehoon Sim, et al.
Published: (2020)

Co-Encapsulation of Simvastatin and Doxorubicin into pH-Sensitive Liposomes Enhances Antitumoral Activity in Breast Cancer Cell Lines
by: Jaqueline Aparecida Duarte, et al.
Published: (2023)

Lung cancer combination therapy: doxorubicin and β-elemene co-loaded, pH-sensitive nanostructured lipid carriers
by: Cao C, et al.
Published: (2019)

Bioresponsive immune-booster-based prodrug nanogel for cancer immunotherapy
by: Xianbin Ma, et al.
Published: (2022)

GSH-sensitive polymeric prodrug: Synthesis and loading with photosensitizers as nanoscale chemo-photodynamic anti-cancer nanomedicine
by: Lei Luo, et al.
Published: (2022)

Synthesis and Characterization of pH-Sensitive Inulin Conjugate of Isoniazid for Monocyte-Targeted Delivery
by: Franklin Afinjuomo, et al.
Published: (2019)

Synthesis and In Vitro Assessment of pH-Sensitive Human Serum Albumin Conjugates of Pirarubicin
by: Kenji Tsukigawa, et al.
Published: (2020)

Co-delivery of doxorubicin and paclitaxel by reduction/pH dual responsive nanocarriers for osteosarcoma therapy
by: Yongshuang Li, et al.
Published: (2020)

Simultaneous determination of doxorubicin and its dipeptide prodrug in mice plasma by HPLC with fluorescence detection
by: Jing Han, et al.
Published: (2016)

Combination prostate cancer therapy: Prostate-specific membranes antigen targeted, pH-sensitive nanoparticles loaded with doxorubicin and tanshinone
by: Guanxing Sun, et al.
Published: (2021)

Overcoming MDR by Associating Doxorubicin and pH-Sensitive PLGA Nanoparticles Containing a Novel Organoselenium Compound-An In Vitro Study
by: Letícia Bueno Macedo, et al.
Published: (2021)

In Vitro and In Vivo Effect of pH-Sensitive PLGA-TPGS-Based Hybrid Nanoparticles Loaded with Doxorubicin for Breast Cancer Therapy
by: Renata S. Fernandes, et al.
Published: (2022)

Investigation of the Antitumor Activity and Toxicity of Tumor-Derived Exosomes Fused with Long-Circulating and pH-Sensitive Liposomes Containing Doxorubicin
by: Eliza Rocha Gomes, et al.
Published: (2022)

Remote loading paclitaxel-doxorubicin prodrug into liposomes for cancer combination therapy
by: Jiang Yu, et al.
Published: (2020)

pH-Sensitive Mixed Micelles Assembled from PDEAEMA-PPEGMA and PCL-PPEGMA for Doxorubicin Delivery: Experimental and DPD Simulations Study
by: Chufen Yang, et al.
Published: (2020)

Pharmacokinetics of a ternary conjugate based pH-responsive 10-HCPT prodrug nano-micelle delivery system
by: Yang Liu, et al.
Published: (2017)

Synergy effects of copper ion in doxorubicin-based chelate prodrug for cancer chemo-chemodynamic combination therapy
by: Wen Zhang, et al.
Published: (2023)

Synthesis and Biochemical Evaluation of Baicalein Prodrugs
by: Sang-Hyun Son, et al.
Published: (2021)

Preparation and evaluation of poly(l-histidine) based pH-sensitive micelles for intracellular delivery of doxorubicin against MCF-7/ADR cells
by: Nan Jia, et al.
Published: (2017)

Optimized 5-Fluorouridine Prodrug for Co-Loading with Doxorubicin in Clinically Relevant Liposomes
by: Debra Wu, et al.
Published: (2021)

Sericin nanomicelles with enhanced cellular uptake and pH-triggered release of doxorubicin reverse cancer drug resistance
by: Weihong Guo, et al.
Published: (2018)

Progress in pH-Sensitive sensors: essential tools for organelle pH detection, spotlighting mitochondrion and diverse applications
by: Shu-Ang Li, et al.
Published: (2024)

pH-sensitive micelles self-assembled from star-shaped TPGS copolymers with ortho ester linkages for enhanced MDR reversal and chemotherapy
by: Yong Xu, et al.
Published: (2021)

Statement of Retraction: Bicomponent polymeric micelles for pH-controlled delivery of doxorubicin
Published: (2024)

Stability of freeze-dried pH-responsive dextrin nanogels containing doxorubicin
by: Somkamol Manchun, et al.
Published: (2016)

Engineering prodrug nanomicelles as pyroptosis inducer for codelivery of PI3K/mTOR and CDK inhibitors to enhance antitumor immunity
by: Qichao Yang, et al.
Published: (2022)

Preparation and evaluation of 2-methoxyestradiol-loaded pH-sensitive liposomes
by: Suna He, et al.

Celecoxib coupled to dextran via a glutamic acid linker yields a polymeric prodrug suitable for colonic delivery
by: Lee Y, et al.
Published: (2015)

Synthesis of new derivatives of Ceftazidime as possible Prodrugs
by: Shakir M. Alwan, et al.
Published: (2017)