The beneficial roles of apelin-13/APJ system in cerebral ischemia: Pathogenesis and therapeutic strategies
The incidence of cerebral ischemia has increased in the past decades, and the high fatality and disability rates seriously affect human health. Apelin is a bioactive peptide and the ligand of the G protein-coupled receptor APJ. Both are ubiquitously expressed in the peripheral and central nervous sy...
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Frontiers Media S.A.,
2022-08-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_85d0930b2d1f470c94e18dfbeb1c87bf | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Jiabin Li |e author |
| 700 | 1 | 0 | |a Zhang Chen |e author |
| 700 | 1 | 0 | |a Jingyu Chen |e author |
| 700 | 1 | 0 | |a Yue Yu |e author |
| 245 | 0 | 0 | |a The beneficial roles of apelin-13/APJ system in cerebral ischemia: Pathogenesis and therapeutic strategies |
| 260 | |b Frontiers Media S.A., |c 2022-08-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2022.903151 | ||
| 520 | |a The incidence of cerebral ischemia has increased in the past decades, and the high fatality and disability rates seriously affect human health. Apelin is a bioactive peptide and the ligand of the G protein-coupled receptor APJ. Both are ubiquitously expressed in the peripheral and central nervous systems, and regulate various physiological and pathological process in the cardiovascular, nervous and endocrine systems. Apelin-13 is one of the subtypes of apelin, and the apelin-13/APJ signaling pathway protects against cerebral ischemia by promoting angiogenesis, inhibiting excitotoxicity and stabilizing atherosclerotic plaques. In this review, we have discussed the role of apelin-13 in the regulation of cerebral ischemia and the underlying mechanisms, along with the therapeutic potential of the apelin-13/APJ signaling pathway in cerebral ischemia. | ||
| 546 | |a EN | ||
| 690 | |a apelin-13 | ||
| 690 | |a APJ | ||
| 690 | |a cerebral ischemia | ||
| 690 | |a pathway | ||
| 690 | |a angiogenesis | ||
| 690 | |a atherosclerotic plaque | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 13 (2022) | |
| 787 | 0 | |n https://www.frontiersin.org/articles/10.3389/fphar.2022.903151/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/85d0930b2d1f470c94e18dfbeb1c87bf |z Connect to this object online. |