Obesity, inflammation, and insulin resistance

White adipose tissue (WAT) is considered an endocrine organ. When present in excess, WAT can influence metabolism via biologically active molecules. Following unregulated production of such molecules, adipose tissue dysfunction results, contributing to complications associated with obesity. Previous...

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Bibliographic Details
Main Authors: Luana Mota Martins (Author), Ana Raquel Soares Oliveira (Author), Kyria Jayanne Clímaco Cruz (Author), Francisco Leonardo Torres-Leal (Author), Dilina do Nascimento Marreiro (Author)
Format: Book
Published: Universidade de São Paulo, 2014-12-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Luana Mota Martins  |e author 
700 1 0 |a Ana Raquel Soares Oliveira  |e author 
700 1 0 |a Kyria Jayanne Clímaco Cruz  |e author 
700 1 0 |a Francisco Leonardo Torres-Leal  |e author 
700 1 0 |a Dilina do Nascimento Marreiro  |e author 
245 0 0 |a Obesity, inflammation, and insulin resistance 
260 |b Universidade de São Paulo,   |c 2014-12-01T00:00:00Z. 
500 |a 2175-9790 
500 |a 10.1590/S1984-82502014000400003 
520 |a White adipose tissue (WAT) is considered an endocrine organ. When present in excess, WAT can influence metabolism via biologically active molecules. Following unregulated production of such molecules, adipose tissue dysfunction results, contributing to complications associated with obesity. Previous studies have implicated pro- and anti-inflammatory substances in the regulation of inflammatory response and in the development of insulin resistance. In obese individuals, pro-inflammatory molecules produced by adipose tissue contribute to the development of insulin resistance and increased risk of cardiovascular disease. On the other hand, the molecules with anti-inflammatory action, that have been associated with the improvement of insulin sensitivity, have your decreased production. Imbalance of these substances contributes significantly to metabolic disorders found in obese individuals. The current review aims to provide updated information regarding the activity of biomolecules produced by WAT. 
546 |a EN 
690 |a Obesidade 
690 |a Inflamação 
690 |a Tecido adiposo 
690 |a Adipocinas 
690 |a Resistência à insulina 
690 |a Pharmacy and materia medica 
690 |a RS1-441 
655 7 |a article  |2 local 
786 0 |n Brazilian Journal of Pharmaceutical Sciences, Vol 50, Iss 4, Pp 677-692 (2014) 
787 0 |n http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400677&lng=en&tlng=en 
787 0 |n https://doaj.org/toc/2175-9790 
856 4 1 |u https://doaj.org/article/85d3ae8b92ba4568a2fc485c48bbcd7c  |z Connect to this object online.