Synthetic Design and Biological Evaluation of New p53-MDM2 Interaction Inhibitors Based on Imidazoline Core
The use of p53-MDM2 inhibitors is a prospective strategy in anti-cancer therapy for tumors expressing wild type p53 protein. In this study, we have applied a simple approach of two-step synthesis of imidazoline-based alkoxyaryl compounds, which are able to efficiently inhibit p53-MDM2 protein-protei...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Book |
| Published: |
MDPI AG,
2022-04-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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