Polymer Matrix and Manufacturing Methods in Solid Dispersion System for Enhancing Andrographolide Solubility and Absorption: A Systematic Review

• Main Authors: Pratchaya Tipduangta (Author), Sunee Chansakaow (Author), Pimpimon Tansakul (Author), Rungarun Meungjai (Author), Piyameth Dilokthornsakul (Author)
• Format: Book
• Published: MDPI AG, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<b>Background:</b> Andrographolide (ADG) has poor aqueous solubility and low bioavailability. This study systematically reviews the use of solid dispersion (SD) techniques to enhance the solubility and absorption of ADG, with a focus on the methods and polymers utilized. <b>Methodology:</b> We searched electronic databases including PubMed, Web of Science, Scopus^®, Embase and ScienceDirect Elsevier^® up to November 2023 for studies on the solubility or absorption of ADG in SD formulations. Two reviewers independently reviewed the retrieved articles and extracted data using a standardized form and synthesized the data qualitatively. <b>Results:</b> SD significantly improved ADG solubility with up to a 4.7-fold increase and resulted in a decrease in 50% release time (T_1/2) to less than 5 min. SD could also improve ADG absorption, as evidenced by higher C_max and AUC and reduced T_max. Notably, Soluplus-based SDs showed marked solubility and absorption enhancements. Among the five SD techniques (rotary evaporation, spray drying, hot-melt extrusion, freeze drying and vacuum drying) examined, spray drying emerged as the most effective, enabling a one-step process without the need for post-milling. <b>Conclusions:</b> SD techniques, particularly using Soluplus and spray drying, effectively enhance the solubility and absorption of ADG. This insight is vital for the future development of ADG-SD matrices.

Item Description

10.3390/pharmaceutics16050688
1999-4923