Assessment of Sclerodermoid Chronic Graft-versus-host Disease with Colour Doppler Ultrasound

• Main Authors: Priscila Giavedoni (Author), Carmen Martinez (Author), Sebastian Podlipnik (Author), María Suárez-Lleidó (Author), Ignasi Martí-Martí (Author), Daniel Morgado-Carrasco (Author), Montserrat Rovira (Author), Francesc Fernández-Avilés (Author), Gonzalo Gutiérrez (Author), Laura Rosiñol (Author), Joan Cid (Author), Miquel Lozano (Author), José Manuel Mascaró, Jr (Author)
• Format: Book
• Published: Medical Journals Sweden, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 0001-5555; 1651-2057; 10.2340/00015555-3747
• Keywords: graft-versus-host disease; doppler ultrasound; diagnosis; sclerodermoid; inflammation; allogeneic haematopoietic stem cell transplantation; Dermatology; RL1-803
• Source: Acta Dermato-Venereologica, Vol 101, Iss 2, p adv00395 (2021)

Sclerodermoid chronic graft-versus-host disease (scGVHD) is a severe complication of allogeneic haema­- topoietic stem cell transplantation. The aim of this study was to investigate the usefulness of high-frequency ultrasound of the skin in assessing the inflammatory patterns and prognosis of patients with scGVHD. A prospective study was carried out with patients who developed scGVHD in the period June 2016 to April 2018. Clinical and ultrasound examinations were performed on the first visit and at 6-month follow-up. A total of 24 patients were included in the study. A 6-month follow-up high-frequency ultrasound of the skin was performed on 20 of the 24 patients. Abnormal B-mode findings in high-frequency ultrasound of the skin consisted of hypoechogenic dermis, hypoechogenicity of septa and hyperechogenicity of lobules in hypodermis. No differences were observed in these basal parameters between treatment progressive/non-responding and inactive/responding scGVHD groups of patients. Basal Doppler showing increased vascular flow with a systolic peak ≥10 cm/s and a vascular resistance index ≥ 0.70 was observed only in those patients who developed progressive/non-responding scGVHD (62.5% vs 0% p = 0.006). In conclusion, Doppler ultrasound is a useful tool to assess the inflammatory activity and outcome of scGVHD. These findings could enhance patient management and help to guide treatment decisions.