Metformin-mediated effects on mesenchymal stem cells and mechanisms: proliferation, differentiation and aging
Mesenchymal stem cells (MSCs) are a type of pluripotent adult stem cell with strong self-renewal and multi-differentiation abilities. Their excellent biological traits, minimal immunogenicity, and abundant availability have made them the perfect seed cells for treating a wide range of diseases. Afte...
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Frontiers Media S.A.,
2024-08-01T00:00:00Z.
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| 001 | doaj_86921aa1c8d74e178e35ca0f1cea86ef | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Xinjuan Liu |e author |
| 700 | 1 | 0 | |a Zekun Li |e author |
| 700 | 1 | 0 | |a Luyun Liu |e author |
| 700 | 1 | 0 | |a Ping Zhang |e author |
| 700 | 1 | 0 | |a Yue Wang |e author |
| 700 | 1 | 0 | |a Gang Ding |e author |
| 245 | 0 | 0 | |a Metformin-mediated effects on mesenchymal stem cells and mechanisms: proliferation, differentiation and aging |
| 260 | |b Frontiers Media S.A., |c 2024-08-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2024.1465697 | ||
| 520 | |a Mesenchymal stem cells (MSCs) are a type of pluripotent adult stem cell with strong self-renewal and multi-differentiation abilities. Their excellent biological traits, minimal immunogenicity, and abundant availability have made them the perfect seed cells for treating a wide range of diseases. After more than 60 years of clinical practice, metformin is currently one of the most commonly used hypoglycaemic drugs for type 2 diabetes in clinical practice. In addition, metformin has shown great potential in the treatment of various systemic diseases except for type 2 diabetes in recent years, and the mechanisms are involved with antioxidant stress, anti-inflammatory, and induced autophagy, etc. This article reviews the effects and the underlying mechanisms of metformin on the biological properties, including proliferation, multi-differentiation, and aging, of MSCs in vitro and in vivo with the aim of providing theoretical support for in-depth scientific research and clinical applications in MSCs-mediated disease treatment. | ||
| 546 | |a EN | ||
| 690 | |a mesenchymal stem cells | ||
| 690 | |a metformin | ||
| 690 | |a proliferation | ||
| 690 | |a differentiation | ||
| 690 | |a aging | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 15 (2024) | |
| 787 | 0 | |n https://www.frontiersin.org/articles/10.3389/fphar.2024.1465697/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/86921aa1c8d74e178e35ca0f1cea86ef |z Connect to this object online. |