Impact of the manufacturing technique on the dissolution-enhancement functionality of PEG4000 in Cilostazol tablets

• Main Authors: Obada Sawafta (Author), Sonia Alhadid (Author), Izz Aldeen Abu Awwad (Author), Eman Migdadi (Author), Ahmad Aljaberi (Author)
• Format: Book
• Published: Pensoft Publishers, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cilostazol was selected as poorly-soluble model drug to investigate the impact of the manufacturing method on the excipient functionality of PEG4000 at various levels. Powder blends were prepared by direct compression (DC), wet granulation (WG) and hot-melt extrusion (HME). Characteristics of these...