Copaiba Oil-Based Emulsion as a Natural Chemotherapeutic Agent for the Treatment of Bovine Mastitis: In Vivo Studies

Copaiba oil-resin (COR) extracted from <i>Copaifera reticulata</i> Ducke has been used as a natural chemotherapeutic agent for a wide range of therapeutic applications. This study presents an emulgel design with a high concentration of COR, designed to prevent and treat mastitis. The COR...

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Main Authors: Katieli da Silva Souza Campanholi (Author), Ranulfo Combuca da Silva Junior (Author), Flávia Amanda Pedroso de Morais (Author), Renato Sonchini Gonçalves (Author), Bruna Moura Rodrigues (Author), Magali Soares dos Santos Pozza (Author), Lidiane Vizioli de Castro-Hoshino (Author), Silvio Mayke Leite (Author), Otávio Augusto Capeloto (Author), Mauro Luciano Baesso (Author), Paulo Cesar Pozza (Author), Wilker Caetano (Author)
Format: Book
Published: MDPI AG, 2023-01-01T00:00:00Z.
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001 doaj_86df88e9d0784a17b68f2e070c84c20f
042 |a dc 
100 1 0 |a Katieli da Silva Souza Campanholi  |e author 
700 1 0 |a Ranulfo Combuca da Silva Junior  |e author 
700 1 0 |a Flávia Amanda Pedroso de Morais  |e author 
700 1 0 |a Renato Sonchini Gonçalves  |e author 
700 1 0 |a Bruna Moura Rodrigues  |e author 
700 1 0 |a Magali Soares dos Santos Pozza  |e author 
700 1 0 |a Lidiane Vizioli de Castro-Hoshino  |e author 
700 1 0 |a Silvio Mayke Leite  |e author 
700 1 0 |a Otávio Augusto Capeloto  |e author 
700 1 0 |a Mauro Luciano Baesso  |e author 
700 1 0 |a Paulo Cesar Pozza  |e author 
700 1 0 |a Wilker Caetano  |e author 
245 0 0 |a Copaiba Oil-Based Emulsion as a Natural Chemotherapeutic Agent for the Treatment of Bovine Mastitis: In Vivo Studies 
260 |b MDPI AG,   |c 2023-01-01T00:00:00Z. 
500 |a 10.3390/pharmaceutics15020346 
500 |a 1999-4923 
520 |a Copaiba oil-resin (COR) extracted from <i>Copaifera reticulata</i> Ducke has been used as a natural chemotherapeutic agent for a wide range of therapeutic applications. This study presents an emulgel design with a high concentration of COR, designed to prevent and treat mastitis. The COR was stabilized in a gel matrix constituted by carbopol C934P and Pluronic<sup>®</sup> F127 (ECO formulation) ratios. The permeation study of ECO was accessed by Fourier transform infrared photoacoustic spectroscopy (FTIR-PAS). The results reveal a high capacity of ECO to permeate deep skin layers. Dairy cows with a history of mastitis were used as in vivo models and exposed to ECO treatment. Monitoring of the teat's inflammatory response showed that ECO effectively prevents mastitis. Furthermore, the ECO formulation was able to form a thin film gel on the application side, preventing fly proliferation and significantly reducing the pathogen load. This study reveals a drug that can used as an alternative application for mastitis in human or veterinary clinics. 
546 |a EN 
690 |a bovine mastitis 
690 |a copaiba oil-resin 
690 |a emulgel 
690 |a natural anti-inflammatory 
690 |a photoacoustic 
690 |a permeation study 
690 |a Pharmacy and materia medica 
690 |a RS1-441 
655 7 |a article  |2 local 
786 0 |n Pharmaceutics, Vol 15, Iss 2, p 346 (2023) 
787 0 |n https://www.mdpi.com/1999-4923/15/2/346 
787 0 |n https://doaj.org/toc/1999-4923 
856 4 1 |u https://doaj.org/article/86df88e9d0784a17b68f2e070c84c20f  |z Connect to this object online.