Copaiba Oil-Based Emulsion as a Natural Chemotherapeutic Agent for the Treatment of Bovine Mastitis: In Vivo Studies

• Main Authors: Katieli da Silva Souza Campanholi (Author), Ranulfo Combuca da Silva Junior (Author), Flávia Amanda Pedroso de Morais (Author), Renato Sonchini Gonçalves (Author), Bruna Moura Rodrigues (Author), Magali Soares dos Santos Pozza (Author), Lidiane Vizioli de Castro-Hoshino (Author), Silvio Mayke Leite (Author), Otávio Augusto Capeloto (Author), Mauro Luciano Baesso (Author), Paulo Cesar Pozza (Author), Wilker Caetano (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.3390/pharmaceutics15020346; 1999-4923
• Keywords: bovine mastitis; copaiba oil-resin; emulgel; natural anti-inflammatory; photoacoustic; permeation study; Pharmacy and materia medica; RS1-441
• Source: Pharmaceutics, Vol 15, Iss 2, p 346 (2023)

Copaiba oil-resin (COR) extracted from <i>Copaifera reticulata</i> Ducke has been used as a natural chemotherapeutic agent for a wide range of therapeutic applications. This study presents an emulgel design with a high concentration of COR, designed to prevent and treat mastitis. The COR was stabilized in a gel matrix constituted by carbopol C934P and Pluronic^® F127 (ECO formulation) ratios. The permeation study of ECO was accessed by Fourier transform infrared photoacoustic spectroscopy (FTIR-PAS). The results reveal a high capacity of ECO to permeate deep skin layers. Dairy cows with a history of mastitis were used as in vivo models and exposed to ECO treatment. Monitoring of the teat's inflammatory response showed that ECO effectively prevents mastitis. Furthermore, the ECO formulation was able to form a thin film gel on the application side, preventing fly proliferation and significantly reducing the pathogen load. This study reveals a drug that can used as an alternative application for mastitis in human or veterinary clinics.