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Phase I and scintigraphy studies to evaluate safety, tolerability, pharmacokinetics, and lung deposition of inhaled GDC‐0214 in healthy volunteers

Abstract Several inflammatory cytokines that promote inflammation and pathogenesis in asthma signal through the Janus kinase 1 (JAK1) pathway. This phase I, randomized, placebo‐controlled trial assessed the pharmacokinetics and safety of single and multiple ascending doses up to 15 mg twice daily fo...

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Main Authors: Rui Zhu (Author), Hubert Chen (Author), Joshua Galanter (Author), Gaohong She (Author), Fang Cai (Author), Matthew R. Durk (Author), Yixuan Zou (Author), Liuxi Chen (Author), Jane R. Kenny (Author), Shweta Vadhavkar (Author), Simon Warren (Author), Glyn Taylor (Author), Olivia Hwang (Author), Avi Eliahu (Author), Chris Wynne (Author), Ryan Owen (Author)
Format: Book
Published: Wiley, 2022-05-01T00:00:00Z.
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