LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics
Glioblastoma multiforme (GBM) is the most widespread and aggressive subtype of glioma in adult patients. Numerous long non-coding RNAs (lncRNAs) are deregulated or differentially expressed in GBM. These lncRNAs possess unique regulatory functions in GBM cells, ranging from high invasion/migration to...
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| Main Authors: | , , , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2021-06-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Glioblastoma multiforme (GBM) is the most widespread and aggressive subtype of glioma in adult patients. Numerous long non-coding RNAs (lncRNAs) are deregulated or differentially expressed in GBM. These lncRNAs possess unique regulatory functions in GBM cells, ranging from high invasion/migration to recurrence. This review outlines the present status of specific involvement of lncRNAs in GBM pathogenesis, with a focus on their association with key molecular and cellular regulatory mechanisms. Also, we highlighted the potential of different novel RNA-based strategies that may be beneficial for therapeutic purposes. |
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| Item Description: | 2162-2531 10.1016/j.omtn.2021.03.018 |