Surfactant protein-A nanobody-conjugated liposomes loaded with methylprednisolone increase lung-targeting specificity and therapeutic effect for acute lung injury
The advent of nanomedicine requires novel delivery vehicles to actively target their site of action. Here, we demonstrate the development of lung-targeting drug-loaded liposomes and their efficacy, specificity and safety. Our study focuses on glucocorticoids methylprednisolone (MPS), a commonly used...
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| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Book |
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Taylor & Francis Group,
2017-01-01T00:00:00Z.
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| 001 | doaj_878c58768b05496aae6d02a1f77e2fcf | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Nan Li |e author |
| 700 | 1 | 0 | |a Dong Weng |e author |
| 700 | 1 | 0 | |a Shan-Mei Wang |e author |
| 700 | 1 | 0 | |a Yuan Zhang |e author |
| 700 | 1 | 0 | |a Shan-Shan Chen |e author |
| 700 | 1 | 0 | |a Zhao-Fang Yin |e author |
| 700 | 1 | 0 | |a Jiali Zhai |e author |
| 700 | 1 | 0 | |a Judy Scoble |e author |
| 700 | 1 | 0 | |a Charlotte C. Williams |e author |
| 700 | 1 | 0 | |a Tao Chen |e author |
| 700 | 1 | 0 | |a Hui Qiu |e author |
| 700 | 1 | 0 | |a Qin Wu |e author |
| 700 | 1 | 0 | |a Meng-Meng Zhao |e author |
| 700 | 1 | 0 | |a Li-Qin Lu |e author |
| 700 | 1 | 0 | |a Xavier Mulet |e author |
| 700 | 1 | 0 | |a Hui-Ping Li |e author |
| 245 | 0 | 0 | |a Surfactant protein-A nanobody-conjugated liposomes loaded with methylprednisolone increase lung-targeting specificity and therapeutic effect for acute lung injury |
| 260 | |b Taylor & Francis Group, |c 2017-01-01T00:00:00Z. | ||
| 500 | |a 1071-7544 | ||
| 500 | |a 1521-0464 | ||
| 500 | |a 10.1080/10717544.2017.1402217 | ||
| 520 | |a The advent of nanomedicine requires novel delivery vehicles to actively target their site of action. Here, we demonstrate the development of lung-targeting drug-loaded liposomes and their efficacy, specificity and safety. Our study focuses on glucocorticoids methylprednisolone (MPS), a commonly used drug to treat lung injuries. The steroidal molecule was loaded into functionalized nano-sterically stabilized unilamellar liposomes (NSSLs). Targeting functionality was performed through conjugation of surfactant protein A (SPANb) nanobodies to form MPS-NSSLs-SPANb. MPS-NSSLs-SPANb exhibited good size distribution, morphology, and encapsulation efficiency. Animal experiments demonstrated the high specificity of MPS-NSSLs-SPANb to the lung. Treatment with MPS-NSSLs-SPANb reduced the levels of TNF-α, IL-8, and TGF-β1 in rat bronchoalveolar lavage fluid and the expression of NK-κB in the lung tissues, thereby alleviating lung injuries and increasing rat survival. The nanobody functionalized nanoparticles demonstrate superior performance to treat lung injury when compared to that of antibody functionalized systems. | ||
| 546 | |a EN | ||
| 690 | |a acute lung injury | ||
| 690 | |a bioconjugation | ||
| 690 | |a liposomes; lung-targeted drug delivery | ||
| 690 | |a surfactant protein-a | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Drug Delivery, Vol 24, Iss 1, Pp 1770-1781 (2017) | |
| 787 | 0 | |n http://dx.doi.org/10.1080/10717544.2017.1402217 | |
| 787 | 0 | |n https://doaj.org/toc/1071-7544 | |
| 787 | 0 | |n https://doaj.org/toc/1521-0464 | |
| 856 | 4 | 1 | |u https://doaj.org/article/878c58768b05496aae6d02a1f77e2fcf |z Connect to this object online. |