Surfactant protein-A nanobody-conjugated liposomes loaded with methylprednisolone increase lung-targeting specificity and therapeutic effect for acute lung injury

• Main Authors: Nan Li (Author), Dong Weng (Author), Shan-Mei Wang (Author), Yuan Zhang (Author), Shan-Shan Chen (Author), Zhao-Fang Yin (Author), Jiali Zhai (Author), Judy Scoble (Author), Charlotte C. Williams (Author), Tao Chen (Author), Hui Qiu (Author), Qin Wu (Author), Meng-Meng Zhao (Author), Li-Qin Lu (Author), Xavier Mulet (Author), Hui-Ping Li (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The advent of nanomedicine requires novel delivery vehicles to actively target their site of action. Here, we demonstrate the development of lung-targeting drug-loaded liposomes and their efficacy, specificity and safety. Our study focuses on glucocorticoids methylprednisolone (MPS), a commonly used...