Cover Image

Population Pharmacokinetic Analysis of the BTK Inhibitor Zanubrutinib in Healthy Volunteers and Patients With B‐Cell Malignancies

Zanubrutinib is a potent, second‐generation Bruton's tyrosine kinase inhibitor that is currently being investigated in patients with B‐cell malignancies and recently received accelerated approval in the United States for treatment of relapsed/refractory mantle cell lymphoma. The objective of th...

Full description

Saved in:

Bibliographic Details
Main Authors:	Ying C. Ou (Author), Lucy Liu (Author), Bilal Tariq (Author), Kun Wang (Author), Ashutosh Jindal (Author), Zhiyu Tang (Author), Yuying Gao (Author), Srikumar Sahasranaman (Author)
Format:	Book
Published:	Wiley, 2021-03-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Comprehensive PBPK model to predict drug interaction potential of Zanubrutinib as a victim or perpetrator
by: Kun Wang, et al.
Published: (2021)

In vitro investigations into the roles of CYP450 enzymes and drug transporters in the drug interactions of zanubrutinib, a covalent Bruton's tyrosine kinase inhibitor
by: Heather Zhang, et al.
Published: (2021)

No QTc Prolongation With Zanubrutinib: Results of Concentration‐QTc Analysis From a Thorough QT Study in Healthy Subjects
by: Song Mu, et al.
Published: (2020)

Safety, Tolerability, Pharmacokinetics, Target Occupancy, and Concentration‐QT Analysis of the Novel BTK Inhibitor Evobrutinib in Healthy Volunteers
by: Andreas Becker, et al.
Published: (2020)

A phase I trial assessing the safety, pharmacokinetics, cerebrospinal fluid penetrance, and food effect of BTK inhibitor tolebrutinib in healthy volunteers
by: Marie‐José Cabanis, et al.
Published: (2024)

Model‐based population pharmacokinetic analysis of tislelizumab in patients with advanced tumors
by: Nageshwar Budha, et al.
Published: (2023)

Use of modeling and simulation to predict the influence of triazole antifungal agents on the pharmacokinetics of zanubrutinib and acalabrutinib
by: Lu Chen, et al.
Published: (2022)

Safety, pharmacokinetics, and pharmacodynamics of sofnobrutinib, a novel non‐covalent BTK inhibitor, in healthy subjects: First‐in‐human phase I study
by: Kyoko Miyamoto, et al.
Published: (2024)

Pharmacokinetics of intranasal amiloride in healthy volunteers
by: Venkata K. Yellepeddi, et al.
Published: (2023)

Zanubrutinib in Treating Waldenström Macroglobulinemia, the Last Shall Be the First
by: Deshpande A, et al.
Published: (2022)

Effect of Probenecid on Pharmacokinetics and Tolerability of Olmesartan in Healthy Chinese Volunteers
by: Kun-Yan Li, PhD, et al.
Published: (2014)

Effect of Rifampicin on the Pharmacokinetics of Evogliptin in Healthy Volunteers
by: Shin Y, et al.
Published: (2022)

Population pharmacokinetics of olprinone in healthy male volunteers
by: Kunisawa T, et al.
Published: (2014)

Study of GABA in healthy volunteers: pharmacokinetics and pharmacodynamics
by: Junfeng eLi, et al.
Published: (2015)

The effects of rabeprazole on metformin pharmacokinetics and pharmacodynamics in Chinese healthy volunteers
by: Guojing Liu, et al.
Published: (2016)

Effects of probenecid and cimetidine on the pharmacokinetics of nemonoxacin in healthy Chinese volunteers
by: Zhang YF, et al.
Published: (2016)

Comparative CNS Pharmacology of the Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib Versus Other BTK Inhibitor Candidates for Treating Multiple Sclerosis
by: Timothy J. Turner, et al.
Published: (2024)

Clinical dose rationale of tislelizumab in patients with solid or hematological advanced tumors
by: Tian Yu, et al.
Published: (2024)

Effect of Efavirenz on the Pharmacokinetics of SHR6390 in Healthy Volunteers
by: Wang J, et al.
Published: (2024)

Effect of tea constituents on paracetamol pharmacokinetics in healthy volunteers
by: Preethi Soysa, et al.
Published: (2012)

Evaluation of the Effect of Food on the Pharmacokinetics of SHR6390, An Oral CDK4/6 Inhibitor, in Healthy Volunteers
by: Yan-ping Liu, et al.
Published: (2022)

ASK120067 potently suppresses B-cell or T-cell malignancies in vitro and in vivo by inhibiting BTK and ITK
by: Peiran Song, et al.
Published: (2022)

Zanubrutinib-induced aseptic meningitis: a case report and literature review
by: Jinjun Yang, et al.
Published: (2023)

Bruton's Tyrosine Kinase Inhibitor Zanubrutinib Effectively Modulates Cancer Resistance by Inhibiting Anthracycline Metabolism and Efflux
by: Lucie Čermáková, et al.
Published: (2022)

Pharmacokinetic interaction between fimasartan and atorvastatin in healthy male volunteers
by: Choi Y, et al.
Published: (2018)

Clinical pharmacokinetics of atropine oral gel formulation in healthy volunteers
by: Madison Parrot, et al.
Published: (2024)

Population Pharmacokinetics and Pharmacodynamics of Benralizumab in Healthy Volunteers and Patients With Asthma
by: B Wang, et al.
Published: (2017)

Effects of dexamethasone coadministered with oseltamivir on the pharmacokinetics of oseltamivir in healthy volunteers
by: Jang K, et al.
Published: (2017)

ZYBT1, a potent, irreversible Bruton's Tyrosine Kinase (BTK) inhibitor that inhibits the C481S BTK with profound efficacy against arthritis and cancer
by: Krishnarup Ghoshdastidar, et al.
Published: (2020)

Evaluation of the safety, tolerability, and pharmacokinetics of RO7049389 in healthy Chinese volunteers
by: Xiaojie Wu, et al.
Published: (2022)

Population pharmacokinetic analysis of transdermal granisetron in healthy Chinese and Caucasian volunteers
by: Jiayu Li, et al.
Published: (2023)

A Pharmacokinetic Drug Interaction Between Fimasartan and Linagliptin in Healthy Volunteers
by: Kang WY, et al.
Published: (2020)

Safety, Tolerability and Pharmacokinetics of Single and Repeat Doses of Vixotrigine in Healthy Volunteers
by: Himanshu Naik, et al.
Published: (2021)

Impact of Green Tea Catechin Ingestion on the Pharmacokinetics of Lisinopril in Healthy Volunteers
by: Shingen Misaka, et al.
Published: (2021)

Pharmacokinetics comparison of two pegylated interferon alfa formulations in healthy volunteers
by: Marisa Boff Costa, et al.
Published: (2018)

Single dose pharmacokinetics of the novel transdermal donepezil patch in healthy volunteers
by: Kim YH, et al.
Published: (2015)

COMPARATIVE PHARMACOKINETICS AND EFFECT ON THE HEMODYNAMICS OF ORIGINAL AND GENERIC NEBIVOLOL IN HEALTHY VOLUNTEERS
by: E. I. Bambysheva, et al.
Published: (2016)

Effect of meal timing on pharmacokinetics and pharmacodynamics of tegoprazan in healthy male volunteers
by: Deok Y. Yoon, et al.
Published: (2021)

Evaluating Novel Agarose-Based Buccal Gels Scaffold: Mucoadhesive and Pharmacokinetic Profiling in Healthy Volunteers
by: Muhammad Ali Syed, et al.
Published: (2022)

Current Perspectives: Evidence to Date on BTK Inhibitors in the Management of Multiple Sclerosis
by: Carnero Contentti E, et al.
Published: (2022)