The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates

• Main Authors: Violeta Georgieva Tsonkova (Author), Fredrik Wolfhagen Sand (Author), Xenia Asbæk Wolf (Author), Lars Groth Grunnet (Author), Anna Kirstine Ringgaard (Author), Camilla Ingvorsen (Author), Louise Winkel (Author), Mark Kalisz (Author), Kevin Dalgaard (Author), Christine Bruun (Author), Johannes Josef Fels (Author), Charlotte Helgstrand (Author), Sven Hastrup (Author), Fredrik Kryh Öberg (Author), Erik Vernet (Author), Michael Paolo Bastner Sandrini (Author), Allan Christian Shaw (Author), Carsten Jessen (Author), Mads Grønborg (Author), Jacob Hald (Author), Hanni Willenbrock (Author), Dennis Madsen (Author), Rasmus Wernersson (Author), Lena Hansson (Author), Jan Nygaard Jensen (Author), Annette Plesner (Author), Tomas Alanentalo (Author), Maja Borup Kjær Petersen (Author), Anne Grapin-Botton (Author), Christian Honoré (Author), Jonas Ahnfelt-Rønne (Author), Jacob Hecksher-Sørensen (Author), Philippe Ravassard (Author), Ole D. Madsen (Author), Claude Rescan (Author), Thomas Frogne (Author)
• Format: Book
• Published: Elsevier, 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: To characterize the EndoC-βH1 cell line as a model for human beta cells and evaluate its beta cell functionality, focusing on insulin secretion, proliferation, apoptosis and ER stress, with the objective to assess its potential as a screening platform for identification of novel anti-diab...