Apnea during slow sub-anaesthetic infusion of intravenous ketamine for treatment-resistant depression

Ketamine's pharmacological profile makes it an interesting and useful drug to challenge treatment-resistant-depression (TRD). Emerging adverse events associated with single-slow-sub-anaesthetic doses for the treatment of depression are common, although generally transient and self-limited. Neve...

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Main Authors: Marcos Gómez-Revuelta (Author), María Fernández-Rodríguez (Author), Laura Boada-Antón (Author), Javier Vázquez-Bourgon (Author)
Format: Book
Published: SAGE Publishing, 2020-12-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Marcos Gómez-Revuelta  |e author 
700 1 0 |a María Fernández-Rodríguez  |e author 
700 1 0 |a Laura Boada-Antón  |e author 
700 1 0 |a Javier Vázquez-Bourgon  |e author 
245 0 0 |a Apnea during slow sub-anaesthetic infusion of intravenous ketamine for treatment-resistant depression 
260 |b SAGE Publishing,   |c 2020-12-01T00:00:00Z. 
500 |a 2045-1261 
500 |a 10.1177/2045125320981498 
520 |a Ketamine's pharmacological profile makes it an interesting and useful drug to challenge treatment-resistant-depression (TRD). Emerging adverse events associated with single-slow-sub-anaesthetic doses for the treatment of depression are common, although generally transient and self-limited. Nevertheless, data on the safety of this practice are scarce. Thus, it seems timely before ketamine is used for clinical treatment of depression to recommend careful monitoring and reporting of all potential adverse events related to ketamine administration. Here, we describe a case of apnea during slow sub-anaesthetic infusion of intravenous ketamine for the treatment of resistant depression. As far as we are concerned, this is an uncommon, previously unreported, and potentially severe adverse event that clinicians should be aware of, and specific management measures should be implemented. 
546 |a EN 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
690 |a Psychiatry 
690 |a RC435-571 
655 7 |a article  |2 local 
786 0 |n Therapeutic Advances in Psychopharmacology, Vol 10 (2020) 
787 0 |n https://doi.org/10.1177/2045125320981498 
787 0 |n https://doaj.org/toc/2045-1261 
856 4 1 |u https://doaj.org/article/883f974ef7144a20b31eaf6d87d93b11  |z Connect to this object online.