Cleavage-embryo genes and transposable elements are regulated by histone variant H2A.X

• Main Authors: Kai-yi SUN (Author), Shi-meng GUO (Author), Gui-ping CHENG (Author), Ying YIN (Author), Ximiao HE (Author), Li-quan ZHOU (Author)
• Format: Book
• Published: The Society for Reproduction and Development, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

During mammalian preimplantation development, stimulation of zygotic genome activation (ZGA) and transposable elements (TEs) shapes totipotency profiling. A rare mouse embryonic stem cells (mESCs) subpopulation is capable of transiently entering a state resembling 2-cell stage embryos, with subtypes...