Plumbagin Prevents Secretory Diarrhea by Inhibiting CaCC and CFTR Channel Activities

• Main Authors: Bo Yu (Author), Xiaojuan Zhu (Author), Xinyu Yang (Author), Lingling Jin (Author), Jia Xu (Author), Tonghui Ma (Author), Hong Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Secretory diarrhea, which primarily originates through intestinal pathogens and viruses, is a health burden in many regions worldwide. Enterocyte Cl− channels, as the final step in enterotoxin-induced fluid secretion, constitute an attractive class of targets for diarrhea therapy. Chloride channel i...