miR-155 Predicts Long-Term Mortality in Critically Ill Patients Younger than 65 Years

Introduction. Alterations in miR-155 serum levels have been described in inflammatory and infectious diseases. Moreover, a role for miR-155 in aging and age-related diseases was recently suggested. We therefore analyzed a potential age-dependent prognostic value of circulating miR-155 as a serum-bas...

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Main Authors: Frank Tacke (Author), Martina E. Spehlmann (Author), Mihael Vucur (Author), Fabian Benz (Author), Mark Luedde (Author), David Vargas Cardenas (Author), Sanchari Roy (Author), Sven Loosen (Author), Hans-Joerg Hippe (Author), Norbert Frey (Author), Christian Trautwein (Author), Alexander Koch (Author), Christoph Roderburg (Author), Tom Luedde (Author)
Format: Book
Published: Hindawi Limited, 2019-01-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Frank Tacke  |e author 
700 1 0 |a Martina E. Spehlmann  |e author 
700 1 0 |a Mihael Vucur  |e author 
700 1 0 |a Fabian Benz  |e author 
700 1 0 |a Mark Luedde  |e author 
700 1 0 |a David Vargas Cardenas  |e author 
700 1 0 |a Sanchari Roy  |e author 
700 1 0 |a Sven Loosen  |e author 
700 1 0 |a Hans-Joerg Hippe  |e author 
700 1 0 |a Norbert Frey  |e author 
700 1 0 |a Christian Trautwein  |e author 
700 1 0 |a Alexander Koch  |e author 
700 1 0 |a Christoph Roderburg  |e author 
700 1 0 |a Tom Luedde  |e author 
245 0 0 |a miR-155 Predicts Long-Term Mortality in Critically Ill Patients Younger than 65 Years 
260 |b Hindawi Limited,   |c 2019-01-01T00:00:00Z. 
500 |a 0962-9351 
500 |a 1466-1861 
500 |a 10.1155/2019/6714080 
520 |a Introduction. Alterations in miR-155 serum levels have been described in inflammatory and infectious diseases. Moreover, a role for miR-155 in aging and age-related diseases was recently suggested. We therefore analyzed a potential age-dependent prognostic value of circulating miR-155 as a serum-based marker in critical illness. Methods. Concentrations of circulating miR-155 were determined in 218 critically ill patients and 76 healthy controls. Results. By using qPCR, we demonstrate that miR-155 serum levels are elevated in patients with critical illness when compared to controls. Notably, levels of circulating miR-155 were independent on the severity of disease, the disease etiology, or the presence of sepsis. In the total cohort, miR-155 was not an indicator for patient survival. Intriguingly, when patients were subdivided according to their age upon admission to the ICU into those younger than 65 years, lower levels of miR-155 turned out as a strong marker, indicating patient mortality with a similar accuracy than other markers frequently used to evaluate critically ill patients on a medical ICU. Conclusion. In summary, the data provided within this study suggest an age-specific role of miR-155 as a prognostic biomarker in patients younger than 65 years. Our study is the first to describe an age-dependent miRNA-based prognostic biomarker in human diseases. 
546 |a EN 
690 |a Pathology 
690 |a RB1-214 
655 7 |a article  |2 local 
786 0 |n Mediators of Inflammation, Vol 2019 (2019) 
787 0 |n http://dx.doi.org/10.1155/2019/6714080 
787 0 |n https://doaj.org/toc/0962-9351 
787 0 |n https://doaj.org/toc/1466-1861 
856 4 1 |u https://doaj.org/article/889fa0170f0e4be398a1ab7cd38e4e30  |z Connect to this object online.