Sphingosine 1-phosphate-induced ICAM-1 expression via NADPH oxidase/ROS-dependent NF-kappaB cascade on human pulmonary alveolar epithelial cells

• Main Authors: Chin-Chung eLin (Author), Chien-Chung eYang (Author), Rou-Ling eCho (Author), Chen-yu eWang (Author), Li-Der eHsiao (Author), Chuen-Mao eYang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The intercellular adhesion molecule-1 (ICAM-1) expression is frequently correlated with the lung inflammation. A bioactive sphingolipid metabolite, sphingosine-1-phosphate (S1P), was involved in inflammation through the adhesion molecules induction, and then caused lung injury. However, the transduc...