Effects of ranolazine on the arrhythmic substrate in hypertrophic cardiomyopathy

• Hlavní autoři: James A. Coleman (Autor), Ruben Doste (Autor), Matteo Beltrami (Autor), Alessia Argirò (Autor), Raffaele Coppini (Autor), Iacopo Olivotto (Autor), Betty Raman (Autor), Alfonso Bueno-Orovio (Autor)
• Médium: Kniha
• Vydáno: Frontiers Media S.A., 2024-04-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Introduction: Hypertrophic cardiomyopathy (HCM) is a leading cause of lethal arrhythmias in the young. Although the arrhythmic substrate has been hypothesised to be amenable to late Na+ block with ranolazine, the specific mechanisms are not fully understood. Therefore, this study aimed to investigat...