Effects of ranolazine on the arrhythmic substrate in hypertrophic cardiomyopathy

• Main Authors: James A. Coleman (Author), Ruben Doste (Author), Matteo Beltrami (Author), Alessia Argirò (Author), Raffaele Coppini (Author), Iacopo Olivotto (Author), Betty Raman (Author), Alfonso Bueno-Orovio (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Hypertrophic cardiomyopathy (HCM) is a leading cause of lethal arrhythmias in the young. Although the arrhythmic substrate has been hypothesised to be amenable to late Na+ block with ranolazine, the specific mechanisms are not fully understood. Therefore, this study aimed to investigat...