Conjugation of a Cationic Cell-Penetrating Peptide with a Novel Kunitzin-like Trypsin Inhibitor: New Insights for Enhancement of Peptide Bioactivities

• Main Authors: Junting Yao (Author), Weining Yin (Author), Yuqing Chen (Author), Xiaoling Chen (Author), Yangyang Jiang (Author), Tao Wang (Author), Chengbang Ma (Author), Mei Zhou (Author), Tianbao Chen (Author), Chris Shaw (Author), Lei Wang (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cationic cell-penetrating peptides (CPPs), such as transactivator of transcription (TAT) peptide, have been proposed as effective drug carriers to improve intracellular delivery of biological macromolecules. Amphibian skin-derived Kunitz-type trypsin inhibitors (KTIs), short counterparts of KTIs fro...