<strong>Analysis of <em> FOXE1</em> rs4460498 and <em> GSTP-1 I105V </em> associated with non syndromic cleft lip and palate among Deutero Malay Subrace in Indonesia</strong>

• Main Authors: Saskia Lenggogeni Nasroen (Author), Florence Meliawaty (Author), Tichvy Tammama (Author), Putri Indriani Prasdiaz (Author), Tias Choirunnisa (Author), Ani Melani Maskoen (Author)
• Format: Book
• Published: Universitas Padjadjaran, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

ABSTRACT Introduction: FOXE1 rs4460498 and GSTP-1 I105V gene polymorphisms are suspected of having a role in some of the non-syndromic cleft lip and palate (NS CLP) populations worldwide. This study aims to analyze FOXE1 rs4460498 and GSTP-1 I105V polymorphisms associated with NS CLP as the risk factor among Deutero Malay Subrace in Indonesia. Methods: This study was a case-control design, using samples from the venous blood of 102 NS CLP subjects and 102 healthy control subjects. After DNA was extracted, the PCR-RFLPs method was performed using TasI restriction enzyme on 100 blood samples of FOXE1 rs4460498 group and Alw26I restriction enzyme on 105 blood samples of the GSTP-1 I105V group. The Chi-Square test was used with the Kolmogorov Smirnov and Exact Fisher alternatives. Results: T mutant allele (OR= 0.926, p>0.05) and CT genotype (OR= 0.0, p>0.05) of FOXE1 rs4460498 and the G mutant allele (OR= 0.988,p>0.05) and AG genotype (OR= 0.675,p>0.05) of the GSTP-1 I105V are not the risks of NS CLP. Conclusion: FOXE1 rs4460498 and GSTP-1 I105V gene polymorphisms are not associated with non-syndromic cleft lip and palate among Deutero Malay Subrace in the Indonesian population. Key words: deutero malay; FOXE1 rs4460498; GSTP-1 I105V; NS CLP

Item Description

1979-0201
2549-6212
10.24198/pjd.vol34no3.39296