Mesenchymal stem cells reversibly de-differentiate myofibroblasts to fibroblast-like cells by inhibiting the TGF-β-SMAD2/3 pathway

• Main Authors: Ruohao Xu (Author), Miao Wu (Author), Yawen Wang (Author), Chao Li (Author), Lingji Zeng (Author), Yulian Wang (Author), Maozhi Xiao (Author), Xiaomei Chen (Author), Suxia Geng (Author), Peilong Lai (Author), Xin Du (Author), Jianyu Weng (Author)
• Format: Book
• Published: BMC, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Myofibroblasts (MFB), one of the major effectors of pathologic fibrosis, mainly derived from the activation of fibroblast to myofibroblast transition (FMT). Although MFBs were historically considered terminally differentiated cells, their potential for de-differentiation was rece...