(Ascorb)ing Pb Neurotoxicity in the Developing Brain

Lead (Pb) neurotoxicity is a major concern, particularly in children. Developmental exposure to Pb can alter neurodevelopmental trajectory and has permanent neuropathological consequences, including an increased vulnerability to further stressors. Ascorbic acid is among most researched antioxidant n...

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Main Authors: Faraz Ahmad (Author), Ping Liu (Author)
Format: Book
Published: MDPI AG, 2020-12-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Faraz Ahmad  |e author 
700 1 0 |a Ping Liu  |e author 
245 0 0 |a (Ascorb)ing Pb Neurotoxicity in the Developing Brain 
260 |b MDPI AG,   |c 2020-12-01T00:00:00Z. 
500 |a 10.3390/antiox9121311 
500 |a 2076-3921 
520 |a Lead (Pb) neurotoxicity is a major concern, particularly in children. Developmental exposure to Pb can alter neurodevelopmental trajectory and has permanent neuropathological consequences, including an increased vulnerability to further stressors. Ascorbic acid is among most researched antioxidant nutrients and has a special role in maintaining redox homeostasis in physiological and physio-pathological brain states. Furthermore, because of its capacity to chelate metal ions, ascorbic acid may particularly serve as a potent therapeutic agent in Pb poisoning. The present review first discusses the major consequences of Pb exposure in children and then proceeds to present evidence from human and animal studies for ascorbic acid as an efficient ameliorative supplemental nutrient in Pb poisoning, with a particular focus on developmental Pb neurotoxicity. In doing so, it is hoped that there is a revitalization for further research on understanding the brain functions of this essential, safe, and readily available vitamin in physiological states, as well to justify and establish it as an effective neuroprotective and modulatory factor in the pathologies of the nervous system, including developmental neuropathologies. 
546 |a EN 
690 |a lead 
690 |a ascorbate 
690 |a neuronal 
690 |a antioxidant 
690 |a chelation 
690 |a nutrient 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Antioxidants, Vol 9, Iss 12, p 1311 (2020) 
787 0 |n https://www.mdpi.com/2076-3921/9/12/1311 
787 0 |n https://doaj.org/toc/2076-3921 
856 4 1 |u https://doaj.org/article/89a4f74f8d9f48c1a19e9a4517dc810f  |z Connect to this object online.