Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia: Suppression of neuroinflammation by blocking NF-κB transcription regulation and activating cAMP/CREB axis

• मुख्य लेखकों: Qian Zhou (लेखक), Meiling Le (लेखक), Yiyi Yang (लेखक), Wenjuan Wang (लेखक), Yuqi Huang (लेखक), Quan Wang (लेखक), Yijing Tian (लेखक), Meiyan Jiang (लेखक), Yong Rao (लेखक), Hai-Bin Luo (लेखक), Yinuo Wu (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2023-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Vascular dementia (VaD) is the second commonest type of dementia which lacks of efficient treatments currently. Neuroinflammation as a prominent pathological feature of VaD, is highly involved in the development of VaD. In order to verify the therapeutic potential of PDE1 inhibitors against VaD, the...