Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia: Suppression of neuroinflammation by blocking NF-κB transcription regulation and activating cAMP/CREB axis

• Hoofdauteurs: Qian Zhou (Auteur), Meiling Le (Auteur), Yiyi Yang (Auteur), Wenjuan Wang (Auteur), Yuqi Huang (Auteur), Quan Wang (Auteur), Yijing Tian (Auteur), Meiyan Jiang (Auteur), Yong Rao (Auteur), Hai-Bin Luo (Auteur), Yinuo Wu (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2023-03-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Vascular dementia (VaD) is the second commonest type of dementia which lacks of efficient treatments currently. Neuroinflammation as a prominent pathological feature of VaD, is highly involved in the development of VaD. In order to verify the therapeutic potential of PDE1 inhibitors against VaD, the...