Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia: Suppression of neuroinflammation by blocking NF-κB transcription regulation and activating cAMP/CREB axis

• Váldodahkkit: Qian Zhou (Dahkki), Meiling Le (Dahkki), Yiyi Yang (Dahkki), Wenjuan Wang (Dahkki), Yuqi Huang (Dahkki), Quan Wang (Dahkki), Yijing Tian (Dahkki), Meiyan Jiang (Dahkki), Yong Rao (Dahkki), Hai-Bin Luo (Dahkki), Yinuo Wu (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2023-03-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Vascular dementia (VaD) is the second commonest type of dementia which lacks of efficient treatments currently. Neuroinflammation as a prominent pathological feature of VaD, is highly involved in the development of VaD. In order to verify the therapeutic potential of PDE1 inhibitors against VaD, the...