18F-fluorodeoxyglucose positron emission tomography and magnetic resonance imaging evaluation of chorea
Chorea is thought to be caused by deactivation of the indirect pathway in the basal ganglia circuit. However, few imaging studies have evaluated the basal ganglia circuit in actual patients with chorea. We investigated the lesions and mechanisms underlying chorea using brain magnetic resonance imagi...
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| Main Authors: | , , , , , |
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| Format: | Book |
| Published: |
MDPI AG,
2018-09-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Chorea is thought to be caused by deactivation of the indirect pathway in the basal ganglia circuit. However, few imaging studies have evaluated the basal ganglia circuit in actual patients with chorea. We investigated the lesions and mechanisms underlying chorea using brain magnetic resonance imaging (MRI) and 18F-fluorodeoxyglucose positron emission tomography (FDG-PET). This retrospective case series included three patients with chorea caused by different diseases: hyperglycemic chorea, Huntington's disease, and subarachnoid hemorrhage. All the patients showed dysfunction in the striatum detected by both MRI and FDG-PET. These neuroimaging findings confirm the theory that chorea is related to an impairment of the indirect pathway of basal ganglia circuit. |
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| Item Description: | 2035-8385 2035-8377 10.4081/ni.2018.7780 |