Safety, tolerability, pharmacokinetics, and pharmacodynamics of a TLR7 agonist prodrug RO6870868 in healthy volunteers

• Päätekijät: Joseph F. Grippo (Tekijä), Ilia Folitar (Tekijä), Sharon Passe (Tekijä), Qiudi Jiang (Tekijä), Ignacio Rodriguez (Tekijä), Scott H. Fettner (Tekijä), Elizabeth Calleja (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Wiley, 2021-07-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Abstract RO6870868 is an oral prodrug of the toll‐like receptor 7 (TLR7) specific agonist, RO6871765. TLR7 agonists augment host immune activity and are in development to treat hepatitis B infection. We evaluated the safety, tolerability, pharmacokinetics (PKs), and pharmacodynamics (PDs) of RO68708...